Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress.

Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM.
Cardiovasc Res. 2008 Jun 1;78(3):505-14. doi: 10.1093/cvr/cvn041. 

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Role of PI3 kinase gamma in excitation-contraction coupling and heart disease.

Oudit GY, Kassiri Z.
Cardiovasc Hematol Disord Drug Targets. 2007 Dec;7(4):295-304. 

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Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury.

Wong DW, Oudit GY, Reich H, Kassiri Z, Zhou J, Liu QC, Backx PH, Penninger JM, Herzenberg AM, Scholey JW.
Am J Pathol. 2007 Aug;171(2):438-51.

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Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.

Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM.
Cardiovasc Res. 2007 Jul 1;75(1):29-39. 

 

Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state.

Sun M, Chen M, Dawood F, Zurawska U, Li JY, Parker T, Kassiri Z, Kirshenbaum LA, Arnold M, Khokha R, Liu PP.
Circulation. 2007 Mar 20;115(11):1398-407. 

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Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3.

Hojilla CV, Kim I, Kassiri Z, Fata JE, Fang H, Khokha R.
J Cell Sci. 2007 Mar 15;120(Pt 6):1050-60. 

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Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis.

Oudit GY, Herzenberg AM, Kassiri Z, Wong D, Reich H, Khokha R, Crackower MA, Backx PH, Penninger JM, Scholey JW.
Am J Pathol. 2006 Jun;168(6):1808-20.

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Individual Timp deficiencies differentially impact pro-MMP-2 activation.
English JL, Kassiri Z, Koskivirta I, Atkinson SJ, Di Grappa M, Soloway PD, Nagase H, Vuorio E, Murphy G, Khokha R.
J Biol Chem. 2006 Apr 14;281(15):10337-46. 

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Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation.
Smookler DS, Mohammed FF, Kassiri Z, Duncan GS, Mak TW, Khokha R.
J Immunol. 2006 Jan 15;176(2):721-5.

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Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy.
Joza N, Oudit GY, Brown D, Bénit P, Kassiri Z, Vahsen N, Benoit L, Patel MM, Nowikovsky K, Vassault A, Backx PH, Wada T, Kroemer G, Rustin P, Penninger JM.
Mol Cell Biol. 2005 Dec;25(23):10261-72.

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Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice.
Kassiri Z, Oudit GY, Sanchez O, Dawood F, Mohammed FF, Nuttall RK, Edwards DR, Liu PP, Backx PH, Khokha R.
Circ Res. 2005 Aug 19;97(4):380-90.

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Albumin activates ERK via EGF receptor in human renal epithelial cells.
Reich H, Tritchler D, Herzenberg AM, Kassiri Z, Zhou X, Gao W, Scholey JW.
J Am Soc Nephrol. 2005 May;16(5):1266-78. 

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Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration.
Mohammed FF, Pennington CJ, Kassiri Z, Rubin JS, Soloway PD, Ruther U, Edwards DR, Khokha R.
Hepatology. 2005 Apr;41(4):857-67.

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Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors.
Kassiri Z, Khokha R.
Thromb Haemost. 2005 Feb;93(2):212-9.

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Distinct functions of junD in cardiac hypertrophy and heart failure.
Ricci R, Eriksson U, Oudit GY, Eferl R, Akhmedov A, Sumara I, Sumara G, Kassiri Z, David JP, Bakiri L, Sasse B, Idarraga MH, Rath M, Kurz D, Theussl HC, Perriard JC, Backx P, Penninger JM, Wagner EF.
Genes Dev. 2005 Jan 15;19(2):208-13.

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Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration.
Mohammed FF, Smookler DS, Taylor SE, Fingleton B, Kassiri Z, Sanchez OH, English JL, Matrisian LM, Au B, Yeh WC, Khokha R.
Nat Genet. 2004 Sep;36(9):969-77.

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TIMP-3 deficiency leads to dilated cardiomyopathy.
Fedak PW, Smookler DS, Kassiri Z, Ohno N, Leco KJ, Verma S, Mickle DA, Watson KL, Hojilla CV, Cruz W, Weisel RD, Li RK, Khokha R.
Circulation. 2004 Oct 19;110(16):2401-9. 

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Prevention of hypertrophy by overexpression of Kv4. 2 in cultured neonatal cardiomyocytes.
Zobel C, Kassiri Z, Meng Y, Backx PH.
Circulation. 2002 Oct 29;106(18):2385-91.doi: 10.1161/01.CIR.0000033970.22130.93

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Molecular components of transient outward potassium current in cultured neonatal rat ventricular myocytes.
Kassiri Z, Hajjar R, Backx PH.
J Mol Med (Berl). 2002 Jun;80(6):351-8. 

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Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes.
Kassiri Z, Zobel C, Nguyen TT, Molkentin JD, Backx PH.
Circ Res. 2002 Mar 22;90(5):578-85.

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The molecular physiology of the cardiac transient outward potassium current (Ito) in normal and diseased myocardium. 
Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH. 
J Mol Cell Cardio. 2001 May;33(5):851-72. doi:10.1006/jmcc.2001.1376.

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Rate‐dependent changes of twitch force duration in rat cardiac trabeculae: a property of the contractile system.
Kassiri Z, Myers R, Kaprielian R, Banijamali H, Backx P.
The Journal of Physiology. 2000 Apr;524(1):221-31. doi: 10.1111/j.1469-7793.2000.t01-3-00221.x. 

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Relationship between K+ channel down‐regulation and [Ca2+] i in rat ventricular myocytes following myocardial infarction. 
Kaprielian R, Wickenden A, Kassiri Z, Parker T, Liu P, Backx P.
The Journal of Physiology. 1999 May;517(1):229-45. doi: 10.1111/j.1469-7793.1999.0229z.x. 

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The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure.
Wickenden AD, Kaprielian R, Kassiri Z, Tsoporis JN, Tsushima R, Fishman GI, Backx PH.
Cardiovasc Res. 1998 Feb;37(2):312-23. doi:10.1016/S0008-6363(97)00256-3.