Multicentric osteolysis with nodulosis, arthritis, and cardiac defect syndrome: loss of MMP2 leads to increased apoptosis with alteration of apoptotic regulators and caspases and embryonic lethality. 
Mosig RA, Schulz R, Kassiri Z, Schaffler MB, Martignetti JA.
Advances in Genomics and Genetics. 2014 Nov 13;4:207-17. doi:10.2147/AGG.S69675

 

Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy.
Haddad G, Zhabyeyev P, Farhan M, Zhu LF, Kassiri Z, Rayner DC, Vanhaesebroeck B, Oudit GY, Murray AG.
Blood. 2014 Sep 25;124(13):2142-9. doi: 10.1182/blood-2014-02-557975.

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The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study.
Ezekowitz JA, Becher H, Belenkie I, Clark AM, Duff HJ, Friedrich MG, Haykowsky MJ, Howlett JG, Kassiri Z, Kaul P, Kim DH, Knudtson ML, Light PE, Lopaschuk GD, McAlister FA, Noga ML, Oudit GY, Paterson DI, Quan H, Schulz R, Thompson RB, Weeks SG, Anderson TJ, Dyck JR.
BMC Cardiovasc Disord. 2014 Jul 25;14:91. doi: 10.1186/1471-2261-14-91.

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Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology.
Putko BN, Wang Z, Lo J, Anderson T, Becher H, Dyck JR, Kassiri Z, Oudit GY; Alberta HEART Investigators.
PLoS One. 2014 Jun 12;9(6):e99495. doi: 10.1371/journal.pone.0099495. eCollection 2014.

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Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm. ​Editorial
Lee J, Shen M, Parajuli N, Oudit GY, McMurtry MS, Kassiri Z.
J Mol Med (Berl). 2014 Sep;92(9):939-49. doi: 10.1007/s00109-014-1178-6. 

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Myocardial recovery from ischemia-reperfusion is compromised in the absence of tissue inhibitor of metalloproteinase 4.
Takawale A, Fan D, Basu R, Shen M, Parajuli N, Wang W, Wang X, Oudit GY, Kassiri Z.
Circ Heart Fail. 2014 Jul;7(4):652-62. doi: 10.1161/CIRCHEARTFAILURE.114.001113. 

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Angiotensin-converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling.
Patel VB, Zhong JC, Fan D, Basu R, Morton JS, Parajuli N, McMurtry MS, Davidge ST, Kassiri Z, Oudit GY.
Hypertension. 2014 Jul;64(1):157-64. doi: 10.1161/HYPERTENSIONAHA.114.03388. 

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Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease.
Wang W, Patel VB, Parajuli N, Fan D, Basu R, Wang Z, Ramprasath T, Kassiri Z, Penninger JM, Oudit GY.
J Mol Med (Berl). 2014 Aug;92(8):847-58. doi: 10.1007/s00109-014-1149-y.

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Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction. ​Editorial
Fan D, Takawale A, Basu R, Patel V, Lee J, Kandalam V, Wang X, Oudit GY, Kassiri Z.
Cardiovasc Res. 2014 Jul 15;103(2):268-80. doi: 10.1093/cvr/cvu072.

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Matrix as an interstitial transport system.
Fan D, Creemers EE, Kassiri Z.
Circ Res. 2014 Feb 28;114(5):889-902. doi: 10.1161/CIRCRESAHA.114.302335. 

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Angiotensin 1-7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation.
Mori J, Patel VB, Abo Alrob O, Basu R, Altamimi T, Desaulniers J, Wagg CS, Kassiri Z, Lopaschuk GD, Oudit GY.
Circ Heart Fail. 2014 Mar 1;7(2):327-39. doi: 10.1161/CIRCHEARTFAILURE.113.000672. 

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Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS.
Patel VB, Clarke N, Wang Z, Fan D, Parajuli N, Basu R, Putko B, Kassiri Z, Turner AJ, Oudit GY.
J Mol Cell Cardiol. 2014 Jan;66:167-76. doi: 10.1016/j.yjmcc.2013.11.017.

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TIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury.
Wang Z, Famulski K, Lee J, Das SK, Wang X, Halloran P, Oudit GY, Kassiri Z.
Kidney Int. 2014 Jan;85(1):82-93. doi: 10.1038/ki.2013.225.