Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury.
Ali MA, Cho WJ, Hudson B, Kassiri Z, Granzier H, Schulz R.
Circulation. 2010 Nov 16;122(20):2039-47. doi: 10.1161/CIRCULATIONAHA.109.930222.

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Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.
Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY.
Circ Res. 2010 Nov 12;107(10):1275-89. doi: 10.1161/CIRCRESAHA.110.229054.

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Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction.
Zhong J, Basu R, Guo D, Chow FL, Byrns S, Schuster M, Loibner H, Wang XH, Penninger JM, Kassiri Z, Oudit GY.
Circulation. 2010 Aug 17;122(7):717-28, 18 p following 728. doi: 10.1161/CIRCULATIONAHA.110.955369.

 

Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction.
Kandalam V, Basu R, Abraham T, Wang X, Awad A, Wang W, Lopaschuk GD, Maeda N, Oudit GY, Kassiri Z.
Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1012-23. doi: 10.1152/ajpheart.00246.2010.  

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Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.
Koskivirta I, Kassiri Z, Rahkonen O, Kiviranta R, Oudit GY, McKee TD, Kytö V, Saraste A, Jokinen E, Liu PP, Vuorio E, Khokha R.
J Biol Chem. 2010 Aug 6;285(32):24487-93. doi: 10.1074/jbc.M110.136820. 

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TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activation.
Kandalam V, Basu R, Abraham T, Wang X, Soloway PD, Jaworski DM, Oudit GY, Kassiri Z.
Circ Res. 2010 Mar 5;106(4):796-808. doi: 10.1161/CIRCRESAHA.109.209189. 

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Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner.
Awad AE, Kandalam V, Chakrabarti S, Wang X, Penninger JM, Davidge ST, Oudit GY, Kassiri Z.
Am J Physiol Cell Physiol. 2010 Mar;298(3):C679-92. doi: 10.1152/ajpcell.00351.2009. Epub 2009 Dec 9. Erratum in: Am J Physiol Cell Physiol. 2014 Ocrt 15;307(8):C760-2.

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Human recombinant ACE2 reduces the progression of diabetic nephropathy.
Oudit GY, Liu GC, Zhong J, Basu R, Chow FL, Zhou J, Loibner H, Janzek E, Schuster M, Penninger JM, Herzenberg AM, Kassiri Z, Scholey JW.
Diabetes. 2010 Feb;59(2):529-38. doi: 10.2337/db09-1218. Epub 2009 Nov 23. Erratum in: Diabetes. 2010 Apr;59(4):1113-4.