Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II.

Basu R, Fan D, Kandalam V, Lee J, Das SK, Wang X, Baldwin TA, Oudit GY, Kassiri Z.
J Biol Chem. 2012 Dec 28;287(53):44083-96. doi: 10.1074/jbc.M112.425652. 

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Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease.

Fan D, Takawale A, Lee J, Kassiri Z.
Fibrogenesis Tissue Repair. 2012 Sep 3;5(1):15. doi: 10.1186/1755-1536-5-15.

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Loss of TIMP3 selectively exacerbates diabetic nephropathy.

Basu R, Lee J, Wang Z, Patel VB, Fan D, Das SK, Liu GC, John R, Scholey JW, Oudit GY, Kassiri Z.
Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1341-52. doi: 10.1152/ajprenal.00349.2012.

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Effects of hypoxia-induced intrauterine growth restriction on cardiac siderosis and oxidative stress. 
Rueda-Clausen C, Morton J, Oudit G, Kassiri Z, Jiang Y, Davidge S.
J Dev Orig Health Dis. 2012 Oct;3(5):350-7. doi:10.1017/S2040174412000219

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Tissue inhibitor of metalloproteinases (TIMPs) in heart failure.

Moore L, Fan D, Basu R, Kandalam V, Kassiri Z.
Heart Fail Rev. 2012 Sep;17(4-5):693-706. doi: 10.1007/s10741-011-9266-y. 

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Agonist-induced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: a metabolic contribution to heart failure with normal ejection fraction.

Mori J, Basu R, McLean BA, Das SK, Zhang L, Patel VB, Wagg CS, Kassiri Z, Lopaschuk GD, Oudit GY.
Circ Heart Fail. 2012 Jul 1;5(4):493-503. doi: 10.1161/CIRCHEARTFAILURE.112.966705.

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ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production.

Jin HY, Song B, Oudit GY, Davidge ST, Yu HM, Jiang YY, Gao PJ, Zhu DL, Ning G, Kassiri Z, Penninger JM, Zhong JC.
PLoS One. 2012;7(6):e38502. doi: 10.1371/journal.pone.0038502. 

 

Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensin-converting enzyme 2-null mice.

Patel VB, Bodiga S, Fan D, Das SK, Wang Z, Wang W, Basu R, Zhong J, Kassiri Z, Oudit GY.
Hypertension. 2012 Jun;59(6):1195-203. doi: 10.1161/HYPERTENSIONAHA.112.191650.

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Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury. 
Rey-Parra GJ, Vadivel A, Coltan L, Hall A, Eaton F, Schuster M, Loibner H, Penninger JM, Kassiri Z, Oudit GY, Thébaud B. 
J Mol Med. 2012 June;90(6):637-47.

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Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis.
Patel VB, Bodiga S, Basu R, Das SK, Wang W, Wang Z, Lo J, Grant MB, Zhong J, Kassiri Z, Oudit GY.
Circ Res. 2012 May 11;110(10):1322-35. doi: 10.1161/CIRCRESAHA.112.268029.