Lack of tissue inhibitor of metalloproteinases 2 leads to exacerbated left ventricular dysfunction and adverse extracellular matrix remodeling in response to biomechanical stress.

Kandalam V, Basu R, Moore L, Fan D, Wang X, Jaworski DM, Oudit GY, Kassiri Z.
Circulation. 2011 Nov 8;124(19):2094-105. doi: 10.1161/CIRCULATIONAHA.111.030338.

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Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia.

Luong C, Rey-Perra J, Vadivel A, Gilmour G, Sauve Y, Koonen D, Walker D, Todd KG, Gressens P, Kassiri Z, Nadeem K, Morgan B, Eaton F, Dyck JR, Archer SL, Thébaud B.
Circulation. 2011 May 17;123(19):2120-31. doi: 10.1161/CIRCULATIONAHA.108.845909. 

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Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit.

Bodiga S, Zhong JC, Wang W, Basu R, Lo J, Liu GC, Guo D, Holland SM, Scholey JW, Penninger JM, Kassiri Z, Oudit GY.
Cardiovasc Res. 2011 Jul 1;91(1):151-61. doi: 10.1093/cvr/cvr036.

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Uncoupling between enhanced excitation-contraction coupling and the response to heart disease: lessons from the PI3Kγ knockout murine model.

Guo D, Thiyam G, Bodiga S, Kassiri Z, Oudit GY.
J Mol Cell Cardiol. 2011 Apr;50(4):606-12. doi: 10.1016/j.yjmcc.2011.01.011.

 

Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2.

Zhong J, Guo D, Chen CB, Wang W, Schuster M, Loibner H, Penninger JM, Scholey JW, Kassiri Z, Oudit GY.
Hypertension. 2011 Feb;57(2):314-22. doi: 10.1161/HYPERTENSIONAHA.110.164244. 

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MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE.

Odenbach J, Wang X, Cooper S, Chow FL, Oka T, Lopaschuk G, Kassiri Z, Fernandez-Patron C.
Hypertension. 2011 Jan;57(1):123-30. doi: 10.1161/HYPERTENSIONAHA.110.159525.