top of page

Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm.

Shen M, Hu M, Fedak PW, Oudit GY, Kassiri Z.

Circ Res. 2018 Jun 21. pii: CIRCRESAHA.118.313181. doi: 10.1161/CIRCRESAHA.118.313181.


LOXury of Inhibiting Fibrosis in Volume Overload Cardiomyopathy.

Jana S, Kassiri Z.

Am J Physiol Heart Circ Physiol. 2018 Jun 1. doi: 10.1152/ajpheart.00315.2018.


TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.

Zhabyeyev P, Das SK, Basu R, Shen M, Patel VB, Kassiri Z, Oudit GY.
Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H978-H990. doi: 10.1152/ajpheart.00597.2017. 


Guidelines for measuring cardiac physiology in mice.

Lindsey ML, Kassiri Z, Virag JAI, de Castro Brás LE, Scherrer-Crosbie M.
Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H733-H752. doi: 10.1152/ajpheart.00339.2017.


Disintegrin and metalloproteinases (ADAMs and ADAM-TSs), the emerging family of proteases in heart physiology and pathology.
Chute M, Jana S, Kassiri Z.  
Curr Opin Physiol. 2018 Feb;1:34-45.doi: 10.1016/j.cophys.2017.07.002


Advanced iron-overload cardiomyopathy in a genetic murine model is rescued by resveratrol therapy.

Das SK, Zhabyeyev P, Basu R, Patel VB, Dyck JRB, Kassiri Z, Oudit GY.
Biosci Rep. 2018 Jan 10;38(1). pii: BSR20171302. doi: 10.1042/BSR20171302. 


Absence of Tissue Inhibitor of Metalloproteinase-4 (TIMP4) ameliorates high fat diet-induced obesity in mice due to defective lipid absorption.

Sakamuri SSVP, Watts R, Takawale A, Wang X, Hernandez-Anzaldo S, Bahitham W, Fernandez-Patron C, Lehner R, Kassiri Z.
Sci Rep. 2017 Jul 24;7(1):6210. doi: 10.1038/s41598-017-05951-4.

Myocardial overexpression of TIMP3 after myocardial infarction exerts beneficial effects by promoting angiogenesis and suppressing early proteolysis.

Takawale A, Zhang P, Azad A, Wang W, Wang X, Murray AG, Kassiri Z.
Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H224-H236. doi: 10.1152/ajpheart.00108.2017. 

Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63-Integrin β1 Interaction.

Takawale A, Zhang P, Patel VB, Wang X, Oudit G, Kassiri Z.
Hypertension. 2017 Jun;69(6):1092-1103. doi: 10.1161/HYPERTENSIONAHA.117.09045. 

Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase.
van der Veen JN, Lingrell S, Gao X, Takawale A, Kassiri Z, Vance DE, Jacobs RL.
J Lipid Res. 2017 Apr;58(4):656-667. doi: 10.1194/jlr.M070631. 

Females Are Protected From Iron-Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress.
Das SK, Patel VB, Basu R, Wang W, DesAulniers J, Kassiri Z, Oudit GY.
J Am Heart Assoc. 2017 Jan 23;6(1). pii: e003456. doi: 10.1161/JAHA.116.003456.

Genetic deletion of soluble epoxide hydrolase provides cardioprotective responses following myocardial infarction in aged mice.
Jamieson KL, Samokhvalov V, Akhnokh MK, Lee K, Cho WJ, Takawale A, Wang X, Kassiri Z, Seubert JM.
Prostaglandins Other Lipid Mediat. 2017 Sep;132:47-58. doi: 10.1016/j.prostaglandins.2017.01.001.

Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage.
Shen M, Morton J, Davidge ST, Kassiri Z.
J Mol Cell Cardiol. 2017 Feb;103:11-21. doi: 10.1016/j.yjmcc.2016.12.001.


Crossing Into the Next Frontier of Cardiac Extracellular Matrix Research.

Spinale FG, Frangogiannis NG, Hinz B, Holmes JW, Kassiri Z, Lindsey ML.
Circ Res. 2016 Oct 28;119(10):1040-1045. 

Modulation of Systemic Metabolism by MMP-2: From MMP-2 Deficiency in Mice to MMP-2 Deficiency in Patients.

Fernandez-Patron C, Kassiri Z, Leung D.
Compr Physiol. 2016 Sep 15;6(4):1935-1949. doi: 10.1002/cphy.c160010.

Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism.

Hernandez-Anzaldo S, Brglez V, Hemmeryckx B, Leung D, Filep JG, Vance JE, Vance DE, Kassiri Z, Lijnen RH, Lambeau G, Fernandez-Patron C.
J Am Heart Assoc. 2016 Sep 30;5(10). pii: e004228.

A Disintegrin and Metalloprotease-17 Regulates Pressure Overload-Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin β1.

Fan D, Takawale A, Shen M, Samokhvalov V, Basu R, Patel V, Wang X, Fernandez-Patron C, Seubert JM, Oudit GY, Kassiri Z.
Hypertension. 2016 Oct;68(4):937-48. doi: 10.1161/HYPERTENSIONAHA.116.07566. 

Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury.

Akhnokh MK, Yang FH, Samokhvalov V, Jamieson KL, Cho WJ, Wagg C, Takawale A, Wang X, Lopaschuk GD, Hammock BD, Kassiri Z, Seubert JM.
Front Pharmacol. 2016 Jun 7;7:133. doi: 10.3389/fphar.2016.00133. eCollection 2016.

Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure.

Sakamuri SS, Takawale A, Basu R, Fedak PW, Freed D, Sergi C, Oudit GY, Kassiri Z.
Transl Res. 2016 Jun;172:30-44. doi: 10.1016/j.trsl.2016.02.006. 

Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice.

van der Veen JN, Lingrell S, Gao X, Quiroga AD, Takawale A, Armstrong EA, Yager JY, Kassiri Z, Lehner R, Vance DE, Jacobs RL.
Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1;310(7):G526-38. doi: 10.1152/ajpgi.00243.2015. 


Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy.
Das SK, Wang W, Zhabyeyev P, Basu R, McLean B, Fan D, Parajuli N, DesAulniers J, Patel VB, Hajjar RJ, Dyck JR, Kassiri Z, Oudit GY.
Sci Rep. 2015 Dec 7;5:18132. doi: 10.1038/srep18132.

Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver.
Hernandez-Anzaldo S, Berry E, Brglez V, Leung D, Yun TJ, Lee JS, Filep JG, Kassiri Z, Cheong C, Lambeau G, Lehner R, Fernandez-Patron C.
J Am Heart Assoc. 2015 Nov 13;4(11). pii: e002553. doi: 10.1161/JAHA.115.002553.


Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is Essential in Post-Myocardial Infarction Repair by Regulating Angiogenesis.
Fan D, Takawale A, Shen M, Wang W, Wang X, Basu R, Oudit GY, Kassiri Z.
Circ Heart Fail. 2015 Sep;8(5):970-9. doi: 10.1161/CIRCHEARTFAILURE.114.002029. 

Extracellular matrix communication and turnover in cardiac physiology and pathology.
Takawale A, Sakamuri SS, Kassiri Z.
Compr Physiol. 2015 Apr;5(2):687-719. doi: 10.1002/cphy.c140045. 

Antagonism of angiotensin 1-7 prevents the therapeutic effects of recombinant human ACE2.
Patel VB, Takawale A, Ramprasath T, Das SK, Basu R, Grant MB, Hall DA, Kassiri Z, Oudit GY.
J Mol Med (Berl). 2015 Sep;93(9):1003-13. doi: 10.1007/s00109-015-1285-z.

Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever.
Berry E, Hernandez-Anzaldo S, Ghomashchi F, Lehner R, Murakami M, Gelb MH, Kassiri Z, Wang X, Fernandez-Patron C.
J Am Heart Assoc. 2015 Mar 27;4(4). pii: e001868. doi: 10.1161/JAHA.115.001868.

Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm. 
Shen M, Lee J, Basu R, Sakamuri SS, Wang X, Fan D, Kassiri Z.
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):888-98. doi: 10.1161/ATVBAHA.114.305115. 

Matrix metalloproteinase-2 mediates a mechanism of metabolic cardioprotection consisting of negative regulation of the sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-CoA reductase pathway in the heart.
Wang X, Berry E, Hernandez-Anzaldo S, Takawale A, Kassiri Z, Fernandez-Patron C.
Hypertension. 2015 Apr;65(4):882-8. doi: 10.1161/HYPERTENSIONAHA.114.04989.

PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.
McLean BA, Zhabyeyev P, Patel VB, Basu R, Parajuli N, DesAulniers J, Murray AG, Kassiri Z, Vanhaesebroeck B, Oudit GY.
Cardiovasc Res. 2015 Mar 1;105(3):292-303. doi: 10.1093/cvr/cvv016.


Multicentric osteolysis with nodulosis, arthritis, and cardiac defect syndrome: loss of MMP2 leads to increased apoptosis with alteration of apoptotic regulators and caspases and embryonic lethality. 
Mosig RA, Schulz R, Kassiri Z, Schaffler MB, Martignetti JA.
Advances in Genomics and Genetics. 2014 Nov 13;4:207-17. doi:10.2147/AGG.S69675


Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy.
Haddad G, Zhabyeyev P, Farhan M, Zhu LF, Kassiri Z, Rayner DC, Vanhaesebroeck B, Oudit GY, Murray AG.
Blood. 2014 Sep 25;124(13):2142-9. doi: 10.1182/blood-2014-02-557975.

The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study.
Ezekowitz JA, Becher H, Belenkie I, Clark AM, Duff HJ, Friedrich MG, Haykowsky MJ, Howlett JG, Kassiri Z, Kaul P, Kim DH, Knudtson ML, Light PE, Lopaschuk GD, McAlister FA, Noga ML, Oudit GY, Paterson DI, Quan H, Schulz R, Thompson RB, Weeks SG, Anderson TJ, Dyck JR.
BMC Cardiovasc Disord. 2014 Jul 25;14:91. doi: 10.1186/1471-2261-14-91.

Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology.
Putko BN, Wang Z, Lo J, Anderson T, Becher H, Dyck JR, Kassiri Z, Oudit GY; Alberta HEART Investigators.
PLoS One. 2014 Jun 12;9(6):e99495. doi: 10.1371/journal.pone.0099495. eCollection 2014.

Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm.
Lee J, Shen M, Parajuli N, Oudit GY, McMurtry MS, Kassiri Z.
J Mol Med (Berl). 2014 Sep;92(9):939-49. doi: 10.1007/s00109-014-1178-6. 

Myocardial recovery from ischemia-reperfusion is compromised in the absence of tissue inhibitor of metalloproteinase 4.
Takawale A, Fan D, Basu R, Shen M, Parajuli N, Wang W, Wang X, Oudit GY, Kassiri Z.
Circ Heart Fail. 2014 Jul;7(4):652-62. doi: 10.1161/CIRCHEARTFAILURE.114.001113. 

Angiotensin-converting enzyme 2 is a critical determinant of angiotensin II-induced loss of vascular smooth muscle cells and adverse vascular remodeling.
Patel VB, Zhong JC, Fan D, Basu R, Morton JS, Parajuli N, McMurtry MS, Davidge ST, Kassiri Z, Oudit GY.
Hypertension. 2014 Jul;64(1):157-64. doi: 10.1161/HYPERTENSIONAHA.114.03388. 

Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease.
Wang W, Patel VB, Parajuli N, Fan D, Basu R, Wang Z, Ramprasath T, Kassiri Z, Penninger JM, Oudit GY.
J Mol Med (Berl). 2014 Aug;92(8):847-58. doi: 10.1007/s00109-014-1149-y.

Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction.
Fan D, Takawale A, Basu R, Patel V, Lee J, Kandalam V, Wang X, Oudit GY, Kassiri Z.
Cardiovasc Res. 2014 Jul 15;103(2):268-80. doi: 10.1093/cvr/cvu072.

Matrix as an interstitial transport system.
Fan D, Creemers EE, Kassiri Z.
Circ Res. 2014 Feb 28;114(5):889-902. doi: 10.1161/CIRCRESAHA.114.302335. 

Angiotensin 1-7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation.
Mori J, Patel VB, Abo Alrob O, Basu R, Altamimi T, Desaulniers J, Wagg CS, Kassiri Z, Lopaschuk GD, Oudit GY.
Circ Heart Fail. 2014 Mar 1;7(2):327-39. doi: 10.1161/CIRCHEARTFAILURE.113.000672. 

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: a positive feedback mechanism in the RAS.
Patel VB, Clarke N, Wang Z, Fan D, Parajuli N, Basu R, Putko B, Kassiri Z, Turner AJ, Oudit GY.
J Mol Cell Cardiol. 2014 Jan;66:167-76. doi: 10.1016/j.yjmcc.2013.11.017.

TIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury.
Wang Z, Famulski K, Lee J, Das SK, Wang X, Halloran P, Oudit GY, Kassiri Z.
Kidney Int. 2014 Jan;85(1):82-93. doi: 10.1038/ki.2013.225.


Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway.

Song B, Zhang ZZ, Zhong JC, Yu XY, Oudit GY, Jin HY, Lu L, Xu YL, Kassiri Z, Shen WF, Gao PJ, Zhu DL.
Circ J. 2013;77(12):2997-3006.

Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues.
Wang W, McKinnie SM, Patel VB, Haddad G, Wang Z, Zhabyeyev P, Das SK, Basu R, McLean B, Kandalam V, Penninger JM, Kassiri Z, Vederas JC, Murray AG, Oudit GY.
J Am Heart Assoc. 2013 Jul 1;2(4):e000249. doi: 10.1161/JAHA.113.000249.

Extracellular Matrix Remodelling and Abdominal Aortic Aneurysm.
Basu R, Kassiri Z.
J Clin Exp Cardiolog. 2013 Jul; 4:259. doi:10.4172/2155-9880.1000259.

Loss of p47phox subunit enhances susceptibility to biomechanical stress and heart failure because of dysregulation of cortactin and actin filaments.
Patel VB, Wang Z, Fan D, Zhabyeyev P, Basu R, Das SK, Wang W, Desaulniers J, Holland SM, Kassiri Z, Oudit GY.
Circ Res. 2013 Jun 7;112(12):1542-56. doi: 10.1161/CIRCRESAHA.111.300299. 

TIMP3 is the primary TIMP to regulate agonist-induced vascular remodelling and hypertension.
Basu R, Lee J, Morton JS, Takawale A, Fan D, Kandalam V, Wang X, Davidge ST, Kassiri Z.
Cardiovasc Res. 2013 Jun 1;98(3):360-71. doi: 10.1093/cvr/cvt067. 

Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload.
Zhabyeyev P, Gandhi M, Mori J, Basu R, Kassiri Z, Clanachan A, Lopaschuk GD, Oudit GY.
Cardiovasc Res. 2013 Mar 15;97(4):676-85. doi: 10.1093/cvr/cvs424. 

Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II.

Basu R, Fan D, Kandalam V, Lee J, Das SK, Wang X, Baldwin TA, Oudit GY, Kassiri Z.
J Biol Chem. 2012 Dec 28;287(53):44083-96. doi: 10.1074/jbc.M112.425652. 

Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease.

Fan D, Takawale A, Lee J, Kassiri Z.
Fibrogenesis Tissue Repair. 2012 Sep 3;5(1):15. doi: 10.1186/1755-1536-5-15.

Loss of TIMP3 selectively exacerbates diabetic nephropathy.

Basu R, Lee J, Wang Z, Patel VB, Fan D, Das SK, Liu GC, John R, Scholey JW, Oudit GY, Kassiri Z.
Am J Physiol Renal Physiol. 2012 Nov 1;303(9):F1341-52. doi: 10.1152/ajprenal.00349.2012.

Effects of hypoxia-induced intrauterine growth restriction on cardiac siderosis and oxidative stress. 
Rueda-Clausen C, Morton J, Oudit G, Kassiri Z, Jiang Y, Davidge S.
J Dev Orig Health Dis. 2012 Oct;3(5):350-7. doi:10.1017/S2040174412000219

Tissue inhibitor of metalloproteinases (TIMPs) in heart failure.

Moore L, Fan D, Basu R, Kandalam V, Kassiri Z.
Heart Fail Rev. 2012 Sep;17(4-5):693-706. doi: 10.1007/s10741-011-9266-y. 

Agonist-induced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: a metabolic contribution to heart failure with normal ejection fraction.

Mori J, Basu R, McLean BA, Das SK, Zhang L, Patel VB, Wagg CS, Kassiri Z, Lopaschuk GD, Oudit GY.
Circ Heart Fail. 2012 Jul 1;5(4):493-503. doi: 10.1161/CIRCHEARTFAILURE.112.966705.

ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production.

Jin HY, Song B, Oudit GY, Davidge ST, Yu HM, Jiang YY, Gao PJ, Zhu DL, Ning G, Kassiri Z, Penninger JM, Zhong JC.
PLoS One. 2012;7(6):e38502. doi: 10.1371/journal.pone.0038502. 


Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensin-converting enzyme 2-null mice.

Patel VB, Bodiga S, Fan D, Das SK, Wang Z, Wang W, Basu R, Zhong J, Kassiri Z, Oudit GY.
Hypertension. 2012 Jun;59(6):1195-203. doi: 10.1161/HYPERTENSIONAHA.112.191650.

Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury. 
Rey-Parra GJ, Vadivel A, Coltan L, Hall A, Eaton F, Schuster M, Loibner H, Penninger JM, Kassiri Z, Oudit GY, Thébaud B. 
J Mol Med. 2012 June;90(6):637-47.

Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis.
Patel VB, Bodiga S, Basu R, Das SK, Wang W, Wang Z, Lo J, Grant MB, Zhong J, Kassiri Z, Oudit GY.
Circ Res. 2012 May 11;110(10):1322-35. doi: 10.1161/CIRCRESAHA.112.268029. 


Lack of tissue inhibitor of metalloproteinases 2 leads to exacerbated left ventricular dysfunction and adverse extracellular matrix remodeling in response to biomechanical stress.

Kandalam V, Basu R, Moore L, Fan D, Wang X, Jaworski DM, Oudit GY, Kassiri Z.
Circulation. 2011 Nov 8;124(19):2094-105. doi: 10.1161/CIRCULATIONAHA.111.030338.

Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia.

Luong C, Rey-Perra J, Vadivel A, Gilmour G, Sauve Y, Koonen D, Walker D, Todd KG, Gressens P, Kassiri Z, Nadeem K, Morgan B, Eaton F, Dyck JR, Archer SL, Thébaud B.
Circulation. 2011 May 17;123(19):2120-31. doi: 10.1161/CIRCULATIONAHA.108.845909. 

Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit.

Bodiga S, Zhong JC, Wang W, Basu R, Lo J, Liu GC, Guo D, Holland SM, Scholey JW, Penninger JM, Kassiri Z, Oudit GY.
Cardiovasc Res. 2011 Jul 1;91(1):151-61. doi: 10.1093/cvr/cvr036.

Uncoupling between enhanced excitation-contraction coupling and the response to heart disease: lessons from the PI3Kγ knockout murine model.

Guo D, Thiyam G, Bodiga S, Kassiri Z, Oudit GY.
J Mol Cell Cardiol. 2011 Apr;50(4):606-12. doi: 10.1016/j.yjmcc.2011.01.011.


Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2.

Zhong J, Guo D, Chen CB, Wang W, Schuster M, Loibner H, Penninger JM, Scholey JW, Kassiri Z, Oudit GY.
Hypertension. 2011 Feb;57(2):314-22. doi: 10.1161/HYPERTENSIONAHA.110.164244. 

MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE.

Odenbach J, Wang X, Cooper S, Chow FL, Oka T, Lopaschuk G, Kassiri Z, Fernandez-Patron C.
Hypertension. 2011 Jan;57(1):123-30. doi: 10.1161/HYPERTENSIONAHA.110.159525. 


Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury.
Ali MA, Cho WJ, Hudson B, Kassiri Z, Granzier H, Schulz R.
Circulation. 2010 Nov 16;122(20):2039-47. doi: 10.1161/CIRCULATIONAHA.109.930222.

Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.
Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY.
Circ Res. 2010 Nov 12;107(10):1275-89. doi: 10.1161/CIRCRESAHA.110.229054.

Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction.
Zhong J, Basu R, Guo D, Chow FL, Byrns S, Schuster M, Loibner H, Wang XH, Penninger JM, Kassiri Z, Oudit GY.
Circulation. 2010 Aug 17;122(7):717-28, 18 p following 728. doi: 10.1161/CIRCULATIONAHA.110.955369.


Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction.
Kandalam V, Basu R, Abraham T, Wang X, Awad A, Wang W, Lopaschuk GD, Maeda N, Oudit GY, Kassiri Z.
Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1012-23. doi: 10.1152/ajpheart.00246.2010.  

Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.
Koskivirta I, Kassiri Z, Rahkonen O, Kiviranta R, Oudit GY, McKee TD, Kytö V, Saraste A, Jokinen E, Liu PP, Vuorio E, Khokha R.
J Biol Chem. 2010 Aug 6;285(32):24487-93. doi: 10.1074/jbc.M110.136820. 

TIMP2 deficiency accelerates adverse post-myocardial infarction remodeling because of enhanced MT1-MMP activity despite lack of MMP2 activation.
Kandalam V, Basu R, Abraham T, Wang X, Soloway PD, Jaworski DM, Oudit GY, Kassiri Z.
Circ Res. 2010 Mar 5;106(4):796-808. doi: 10.1161/CIRCRESAHA.109.209189. 

Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner.
Awad AE, Kandalam V, Chakrabarti S, Wang X, Penninger JM, Davidge ST, Oudit GY, Kassiri Z.
Am J Physiol Cell Physiol. 2010 Mar;298(3):C679-92. doi: 10.1152/ajpcell.00351.2009. Epub 2009 Dec 9. Erratum in: Am J Physiol Cell Physiol. 2014 Ocrt 15;307(8):C760-2.

Human recombinant ACE2 reduces the progression of diabetic nephropathy.
Oudit GY, Liu GC, Zhong J, Basu R, Chow FL, Zhou J, Loibner H, Janzek E, Schuster M, Penninger JM, Herzenberg AM, Kassiri Z, Scholey JW.
Diabetes. 2010 Feb;59(2):529-38. doi: 10.2337/db09-1218. Epub 2009 Nov 23. Erratum in: Diabetes. 2010 Apr;59(4):1113-4.


Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction.

Kassiri Z, Zhong J, Guo D, Basu R, Wang X, Liu PP, Scholey JW, Penninger JM, Oudit GY.
Circ Heart Fail. 2009 Sep;2(5):446-55. doi: 10.1161/CIRCHEARTFAILURE.108.840124. 

Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.

Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z.
Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2096-108. doi: 10.1152/ajpheart.00452.2009. 

Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart.

Kassiri Z, Defamie V, Hariri M, Oudit GY, Anthwal S, Dawood F, Liu P, Khokha R.
J Biol Chem. 2009 Oct 23;284(43):29893-904. doi: 10.1074/jbc.M109.028449.


TACE is a key regulator of agonist-induced cardiac hypertrophy and fibrosis.

Wang X, Oka T, Chow FL, Cooper SB, Odenbach J, Lopaschuk GD, Kassiri Z, Fernandez-Patron C.
Hypertension. 2009 Sep;54(3):575-82. doi: 10.1161/HYPERTENSIONAHA.108.127670. 

SARS‐coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS.
Oudit GY, Kassiri Z, Jiang C, Liu PP, Poutanen SM, Penninger JM, Butany J.
Eur J Clin Invest. 2009 July;39(7):618-25. doi: 10.1111/j.1365-2362.2009.02153.x 

Loss of TIMP3 enhances interstitial nephritis and fibrosis.

Kassiri Z, Oudit GY, Kandalam V, Awad A, Wang X, Ziou X, Maeda N, Herzenberg AM, Scholey JW.
J Am Soc Nephrol. 2009 Jun;20(6):1223-35. doi: 10.1681/ASN.2008050492.

Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.

Wang X, Chow FL, Oka T, Hao L, Lopez-Campistrous A, Kelly S, Cooper S, Odenbach J, Finegan BA, Schulz R, Kassiri Z, Lopaschuk GD, Fernandez-Patron C.
Circulation. 2009 May 12;119(18):2480-9. doi: 10.1161/CIRCULATIONAHA.108.835488.


Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress.

Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM.
Cardiovasc Res. 2008 Jun 1;78(3):505-14. doi: 10.1093/cvr/cvn041. 

Role of PI3 kinase gamma in excitation-contraction coupling and heart disease.

Oudit GY, Kassiri Z.
Cardiovasc Hematol Disord Drug Targets. 2007 Dec;7(4):295-304. 

Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury.

Wong DW, Oudit GY, Reich H, Kassiri Z, Zhou J, Liu QC, Backx PH, Penninger JM, Herzenberg AM, Scholey JW.
Am J Pathol. 2007 Aug;171(2):438-51.

Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice.

Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM.
Cardiovasc Res. 2007 Jul 1;75(1):29-39. 


Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state.

Sun M, Chen M, Dawood F, Zurawska U, Li JY, Parker T, Kassiri Z, Kirshenbaum LA, Arnold M, Khokha R, Liu PP.
Circulation. 2007 Mar 20;115(11):1398-407. 

Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3.

Hojilla CV, Kim I, Kassiri Z, Fata JE, Fang H, Khokha R.
J Cell Sci. 2007 Mar 15;120(Pt 6):1050-60. 

Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis.

Oudit GY, Herzenberg AM, Kassiri Z, Wong D, Reich H, Khokha R, Crackower MA, Backx PH, Penninger JM, Scholey JW.
Am J Pathol. 2006 Jun;168(6):1808-20.

Individual Timp deficiencies differentially impact pro-MMP-2 activation.
English JL, Kassiri Z, Koskivirta I, Atkinson SJ, Di Grappa M, Soloway PD, Nagase H, Vuorio E, Murphy G, Khokha R.
J Biol Chem. 2006 Apr 14;281(15):10337-46. 

Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation.
Smookler DS, Mohammed FF, Kassiri Z, Duncan GS, Mak TW, Khokha R.
J Immunol. 2006 Jan 15;176(2):721-5.

Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy.
Joza N, Oudit GY, Brown D, Bénit P, Kassiri Z, Vahsen N, Benoit L, Patel MM, Nowikovsky K, Vassault A, Backx PH, Wada T, Kroemer G, Rustin P, Penninger JM.
Mol Cell Biol. 2005 Dec;25(23):10261-72.

Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice.
Kassiri Z, Oudit GY, Sanchez O, Dawood F, Mohammed FF, Nuttall RK, Edwards DR, Liu PP, Backx PH, Khokha R.
Circ Res. 2005 Aug 19;97(4):380-90.

Albumin activates ERK via EGF receptor in human renal epithelial cells.
Reich H, Tritchler D, Herzenberg AM, Kassiri Z, Zhou X, Gao W, Scholey JW.
J Am Soc Nephrol. 2005 May;16(5):1266-78. 

Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration.
Mohammed FF, Pennington CJ, Kassiri Z, Rubin JS, Soloway PD, Ruther U, Edwards DR, Khokha R.
Hepatology. 2005 Apr;41(4):857-67.

Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors.
Kassiri Z, Khokha R.
Thromb Haemost. 2005 Feb;93(2):212-9.

Distinct functions of junD in cardiac hypertrophy and heart failure.
Ricci R, Eriksson U, Oudit GY, Eferl R, Akhmedov A, Sumara I, Sumara G, Kassiri Z, David JP, Bakiri L, Sasse B, Idarraga MH, Rath M, Kurz D, Theussl HC, Perriard JC, Backx P, Penninger JM, Wagner EF.
Genes Dev. 2005 Jan 15;19(2):208-13.

Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration.
Mohammed FF, Smookler DS, Taylor SE, Fingleton B, Kassiri Z, Sanchez OH, English JL, Matrisian LM, Au B, Yeh WC, Khokha R.
Nat Genet. 2004 Sep;36(9):969-77.

TIMP-3 deficiency leads to dilated cardiomyopathy.
Fedak PW, Smookler DS, Kassiri Z, Ohno N, Leco KJ, Verma S, Mickle DA, Watson KL, Hojilla CV, Cruz W, Weisel RD, Li RK, Khokha R.
Circulation. 2004 Oct 19;110(16):2401-9. 

Prevention of hypertrophy by overexpression of Kv4. 2 in cultured neonatal cardiomyocytes.
Zobel C, Kassiri Z, Meng Y, Backx PH.
Circulation. 2002 Oct 29;106(18):2385-91.doi: 10.1161/01.CIR.0000033970.22130.93

Molecular components of transient outward potassium current in cultured neonatal rat ventricular myocytes.
Kassiri Z, Hajjar R, Backx PH.
J Mol Med (Berl). 2002 Jun;80(6):351-8. 

Reduction of I(to) causes hypertrophy in neonatal rat ventricular myocytes.
Kassiri Z, Zobel C, Nguyen TT, Molkentin JD, Backx PH.
Circ Res. 2002 Mar 22;90(5):578-85.

The molecular physiology of the cardiac transient outward potassium current (Ito) in normal and diseased myocardium. 
Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH. 
J Mol Cell Cardio. 2001 May;33(5):851-72. doi:10.1006/jmcc.2001.1376.

Rate‐dependent changes of twitch force duration in rat cardiac trabeculae: a property of the contractile system.
Kassiri Z, Myers R, Kaprielian R, Banijamali H, Backx P.
The Journal of Physiology. 2000 Apr;524(1):221-31. doi: 10.1111/j.1469-7793.2000.t01-3-00221.x. 

Relationship between K+ channel down‐regulation and [Ca2+] i in rat ventricular myocytes following myocardial infarction. 
Kaprielian R, Wickenden A, Kassiri Z, Parker T, Liu P, Backx P.
The Journal of Physiology. 1999 May;517(1):229-45. doi: 10.1111/j.1469-7793.1999.0229z.x. 

The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure.
Wickenden AD, Kaprielian R, Kassiri Z, Tsoporis JN, Tsushima R, Fishman GI, Backx PH.
Cardiovasc Res. 1998 Feb;37(2):312-23. doi:10.1016/S0008-6363(97)00256-3.

bottom of page